Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis

Pyrazinamide (PZA), an indispensable component of modern tuberculosis treatment, acts as a key sterilizing drug. While the mechanism of activation of this prodrug into pyrazinoic acid (POA) by Mycobacterium tuberculosis has been extensively studied, not all molecular determinants that confer resista...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Njire, Moses, Wang, Na, Wang, Bangxing, Tan, Yaoju, Cai, Xingshan, Liu, Yanwen, Mugweru, Julius, Guo, Jintao, Hameed, H. M. Adnan, Tan, Shouyong, Liu, Jianxiong, Yew, Wing Wai, Nuermberger, Eric, Lamichhane, Gyanu, Liu, Jinsong, Zhang, Tianyu
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2017
Aiheet:
Mechanisms of Resistance
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487608/
https://ncbi.nlm.nih.gov/pubmed/28438933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00070-17
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia