Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis

Pyrazinamide (PZA), an indispensable component of modern tuberculosis treatment, acts as a key sterilizing drug. While the mechanism of activation of this prodrug into pyrazinoic acid (POA) by Mycobacterium tuberculosis has been extensively studied, not all molecular determinants that confer resista...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Njire, Moses, Wang, Na, Wang, Bangxing, Tan, Yaoju, Cai, Xingshan, Liu, Yanwen, Mugweru, Julius, Guo, Jintao, Hameed, H. M. Adnan, Tan, Shouyong, Liu, Jianxiong, Yew, Wing Wai, Nuermberger, Eric, Lamichhane, Gyanu, Liu, Jinsong, Zhang, Tianyu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2017
Pynciau:
Mechanisms of Resistance
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487608/
https://ncbi.nlm.nih.gov/pubmed/28438933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00070-17
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