Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis

We expressed the wild-type rplC and mutated rplC (Cys154Arg) genes, respectively, in Mycobacterium tuberculosis H37Ra and H37Rv in an attempt to delineate the role of rplC (Cys154Arg) regarding oxazolidinone resistance. An increase of the MICs of linezolid (LZD) and sutezolid (PNU-100480, PNU) again...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Makafe, Gaëlle Guiewi, Cao, Yuanyuan, Tan, Yaoju, Julius, Mugweru, Liu, Zhiyong, Wang, Changwei, Njire, Moses M., Cai, Xingshan, Liu, Tianzhou, Wang, Bangxing, Pang, Wei, Tan, Shouyong, Zhang, Buchang, Yew, Wing Wai, Lamichhane, Gyanu, Guo, Jintao, Zhang, Tianyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862453/
https://ncbi.nlm.nih.gov/pubmed/26953211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00152-16
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