Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis

We expressed the wild-type rplC and mutated rplC (Cys154Arg) genes, respectively, in Mycobacterium tuberculosis H37Ra and H37Rv in an attempt to delineate the role of rplC (Cys154Arg) regarding oxazolidinone resistance. An increase of the MICs of linezolid (LZD) and sutezolid (PNU-100480, PNU) again...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Makafe, Gaëlle Guiewi, Cao, Yuanyuan, Tan, Yaoju, Julius, Mugweru, Liu, Zhiyong, Wang, Changwei, Njire, Moses M., Cai, Xingshan, Liu, Tianzhou, Wang, Bangxing, Pang, Wei, Tan, Shouyong, Zhang, Buchang, Yew, Wing Wai, Lamichhane, Gyanu, Guo, Jintao, Zhang, Tianyu
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2016
Ämnen:
Mechanisms of Resistance
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862453/
https://ncbi.nlm.nih.gov/pubmed/26953211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00152-16
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