Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis

We expressed the wild-type rplC and mutated rplC (Cys154Arg) genes, respectively, in Mycobacterium tuberculosis H37Ra and H37Rv in an attempt to delineate the role of rplC (Cys154Arg) regarding oxazolidinone resistance. An increase of the MICs of linezolid (LZD) and sutezolid (PNU-100480, PNU) again...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Makafe, Gaëlle Guiewi, Cao, Yuanyuan, Tan, Yaoju, Julius, Mugweru, Liu, Zhiyong, Wang, Changwei, Njire, Moses M., Cai, Xingshan, Liu, Tianzhou, Wang, Bangxing, Pang, Wei, Tan, Shouyong, Zhang, Buchang, Yew, Wing Wai, Lamichhane, Gyanu, Guo, Jintao, Zhang, Tianyu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862453/
https://ncbi.nlm.nih.gov/pubmed/26953211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00152-16
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