Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis

We expressed the wild-type rplC and mutated rplC (Cys154Arg) genes, respectively, in Mycobacterium tuberculosis H37Ra and H37Rv in an attempt to delineate the role of rplC (Cys154Arg) regarding oxazolidinone resistance. An increase of the MICs of linezolid (LZD) and sutezolid (PNU-100480, PNU) again...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Makafe, Gaëlle Guiewi, Cao, Yuanyuan, Tan, Yaoju, Julius, Mugweru, Liu, Zhiyong, Wang, Changwei, Njire, Moses M., Cai, Xingshan, Liu, Tianzhou, Wang, Bangxing, Pang, Wei, Tan, Shouyong, Zhang, Buchang, Yew, Wing Wai, Lamichhane, Gyanu, Guo, Jintao, Zhang, Tianyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862453/
https://ncbi.nlm.nih.gov/pubmed/26953211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00152-16
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