Optimization of a murine and human tissue model to recapitulate dermal and pulmonary features of systemic sclerosis

The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclerosis (SSc) studies. It has been reported that systemic delivery of BLM via continuous diffusion from subcutaneously implanted osmotic minipumps can cause fibrosis of the skin, lungs, and other internal organs....

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Watanabe, Tomoya, Nishimoto, Tetsuya, Mlakar, Logan, Heywood, Jonathan, Malaab, Maya, Hoffman, Stanley, Feghali-Bostwick, Carol
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484495/
https://ncbi.nlm.nih.gov/pubmed/28651005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179917
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