Optimization of a murine and human tissue model to recapitulate dermal and pulmonary features of systemic sclerosis

The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclerosis (SSc) studies. It has been reported that systemic delivery of BLM via continuous diffusion from subcutaneously implanted osmotic minipumps can cause fibrosis of the skin, lungs, and other internal organs....

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Pubblicato in:PLoS One
Autori principali: Watanabe, Tomoya, Nishimoto, Tetsuya, Mlakar, Logan, Heywood, Jonathan, Malaab, Maya, Hoffman, Stanley, Feghali-Bostwick, Carol
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484495/
https://ncbi.nlm.nih.gov/pubmed/28651005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179917
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