Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice

Hyperexcitable neuronal networks are mechanistically linked to the pathologic and clinical features of Alzheimer's disease (AD). Astrocytes are a primary defense against hyperexcitability, but their functional phenotype during AD is poorly understood. Here, we found that activated astrocytes in...

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Pubblicato in:J Neurosci
Autori principali: Sompol, Pradoldej, Furman, Jennifer L., Pleiss, Melanie M., Kraner, Susan D., Artiushin, Irina A., Batten, Seth R., Quintero, Jorge E., Simmerman, Linda A., Beckett, Tina L., Lovell, Mark A., Murphy, M. Paul, Gerhardt, Greg A., Norris, Christopher M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481945/
https://ncbi.nlm.nih.gov/pubmed/28559377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0877-17.2017
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