Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury

Increasing evidence suggests that the calcineurin (CN)-dependent transcription factor NFAT (Nuclear Factor of Activated T cells) mediates deleterious effects of astrocytes in progressive neurodegenerative conditions. However, the impact of astrocytic CN/NFAT signaling on neural function/recovery aft...

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Pubblicato in:J Neurosci
Autori principali: Furman, Jennifer L., Sompol, Pradoldej, Kraner, Susan D., Pleiss, Melanie M., Putman, Esther J., Dunkerson, Jacob, Mohmmad Abdul, Hafiz, Roberts, Kelly N., Scheff, Stephen W., Norris, Christopher M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737766/
https://ncbi.nlm.nih.gov/pubmed/26843634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1930-15.2016
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