Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice

Hyperexcitable neuronal networks are mechanistically linked to the pathologic and clinical features of Alzheimer's disease (AD). Astrocytes are a primary defense against hyperexcitability, but their functional phenotype during AD is poorly understood. Here, we found that activated astrocytes in...

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發表在:J Neurosci
Main Authors: Sompol, Pradoldej, Furman, Jennifer L., Pleiss, Melanie M., Kraner, Susan D., Artiushin, Irina A., Batten, Seth R., Quintero, Jorge E., Simmerman, Linda A., Beckett, Tina L., Lovell, Mark A., Murphy, M. Paul, Gerhardt, Greg A., Norris, Christopher M.
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2017
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481945/
https://ncbi.nlm.nih.gov/pubmed/28559377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0877-17.2017
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