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Nucleophosmin (B23) Targets ARF to Nucleoli and Inhibits Its Function
The ARF tumor suppressor is a nucleolar protein that activates p53-dependent checkpoints by binding Mdm2, a p53 antagonist. Despite persuasive evidence that ARF can bind and inactivate Mdm2 in the nucleoplasm, the prevailing view is that ARF exerts its growth-inhibitory activities from within the nu...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2005
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548001/ https://ncbi.nlm.nih.gov/pubmed/15684379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.4.1258-1271.2005 |
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