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Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53
The p53 tumor suppressor is controlled by an interactive network of factors that stimulate or inhibit its transcriptional activity. Within that network, Mdm2 functions as the major antagonist of p53 by promoting its ubiquitylation and degradation. Conversely, Tip60 activates p53 through direct assoc...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4049965/ https://ncbi.nlm.nih.gov/pubmed/24621507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28202 |
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