Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53

The p53 tumor suppressor is controlled by an interactive network of factors that stimulate or inhibit its transcriptional activity. Within that network, Mdm2 functions as the major antagonist of p53 by promoting its ubiquitylation and degradation. Conversely, Tip60 activates p53 through direct assoc...

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Bibliografiske detaljer
Main Authors: Reed, Sara M, Hagen, Jussara, Tompkins, Van S, Thies, Katie, Quelle, Frederick W, Quelle, Dawn E
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2014
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049965/
https://ncbi.nlm.nih.gov/pubmed/24621507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28202
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