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ARF Function Does Not Require p53 Stabilization or Mdm2 Relocalization
It is generally accepted that the ARF tumor suppressor induces p53-dependent growth arrest by sequestering the p53 antagonist Mdm2 in the nucleolus. Previous mutagenic studies of murine ARF suggested that residues 1 through 14 and 26 through 37 were critical for Mdm2 binding, while the latter domain...
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Microbiology
2002
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC134207/ https://ncbi.nlm.nih.gov/pubmed/11739734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.1.196-206.2002 |
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