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ARF Function Does Not Require p53 Stabilization or Mdm2 Relocalization

It is generally accepted that the ARF tumor suppressor induces p53-dependent growth arrest by sequestering the p53 antagonist Mdm2 in the nucleolus. Previous mutagenic studies of murine ARF suggested that residues 1 through 14 and 26 through 37 were critical for Mdm2 binding, while the latter domain...

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Udgivet i:Mol Cell Biol
Principais autores: Korgaonkar, Chandrashekhar, Zhao, Lili, Modestou, Modestos, Quelle, Dawn E.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134207/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11739734/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.1.196-206.2002
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