ARF Function Does Not Require p53 Stabilization or Mdm2 Relocalization
It is generally accepted that the ARF tumor suppressor induces p53-dependent growth arrest by sequestering the p53 antagonist Mdm2 in the nucleolus. Previous mutagenic studies of murine ARF suggested that residues 1 through 14 and 26 through 37 were critical for Mdm2 binding, while the latter domain...
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| Publicado no: | Mol Cell Biol |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134207/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11739734/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.1.196-206.2002 |
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