Nucleophosmin (B23) Targets ARF to Nucleoli and Inhibits Its Function

The ARF tumor suppressor is a nucleolar protein that activates p53-dependent checkpoints by binding Mdm2, a p53 antagonist. Despite persuasive evidence that ARF can bind and inactivate Mdm2 in the nucleoplasm, the prevailing view is that ARF exerts its growth-inhibitory activities from within the nu...

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Bibliographic Details
Main Authors:	Korgaonkar, Chandrashekhar, Hagen, Jussara, Tompkins, Van, Frazier, April A., Allamargot, Chantal, Quelle, Frederick W., Quelle, Dawn E.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology 2005
Subjects:	Signal Transduction
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC548001/ https://ncbi.nlm.nih.gov/pubmed/15684379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.4.1258-1271.2005
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Nucleophosmin (B23) Targets ARF to Nucleoli and Inhibits Its Function

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