An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers

Small-molecule inhibitors targeting growth factor receptors have failed to show efficacy for brain cancers, potentially due to inability to achieve sufficient drug levels in the CNS. Targeting non-oncogene tumor co-dependencies provides an alternative approach, particularly if drugs with high brain...

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Detaylı Bibliyografya
Yayımlandı:Cancer Cell
Asıl Yazarlar: Villa, Genaro R., Hulce, Jonathan J., Zanca, Ciro, Bi, Junfeng, Ikegami, Shiro, Cahill, Gabrielle L., Gu, Yuchao, Lum, Kenneth M., Masui, Kenta, Yang, Huijun, Rong, Xin, Hong, Cynthia, Turner, Kristen M., Liu, Feng, Hon, Gary C., Jenkins, David, Martini, Michael, Armando, Aaron M., Quehenberger, Oswald, Cloughesy, Timothy F., Furnari, Frank B., Cavenee, Webster K., Tontonoz, Peter, Gahman, Timothy C., Shiau, Andrew K., Cravatt, Benjamin F., Mischel, Paul S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479636/
https://ncbi.nlm.nih.gov/pubmed/27746144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.09.008
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