Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance

Cancer cells adapt their signaling in response to nutrient availability. To uncover the mechanisms regulating this process and its functional consequences, we interrogated cell lines, mouse tumor models, and clinical samples of glioblastoma (GBM), the highly lethal brain cancer. We discovered that g...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Masui, Kenta, Tanaka, Kazuhiro, Ikegami, Shiro, Villa, Genaro R., Yang, Huijun, Yong, William H., Cloughesy, Timothy F., Yamagata, Kanato, Arai, Nobutaka, Cavenee, Webster K., Mischel, Paul S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522814/
https://ncbi.nlm.nih.gov/pubmed/26170313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511759112
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