mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma

In cancer, aberrant growth factor receptor signaling reprograms cellular metabolism and global gene transcription to drive aggressive growth, but the underlying mechanisms are not well-understood. Here we show that in the highly lethal brain tumor glioblastoma (GBM), mTOR complex 2 (mTORC2), a criti...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Masui, Kenta, Harachi, Mio, Ikegami, Shiro, Yang, Huijun, Onizuka, Hiromi, Yong, William H., Cloughesy, Timothy F., Muragaki, Yoshihiro, Kawamata, Takakazu, Arai, Nobutaka, Komori, Takashi, Cavenee, Webster K., Mischel, Paul S., Shibata, Noriyuki
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926466/
https://ncbi.nlm.nih.gov/pubmed/31712311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011519
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