mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma

In cancer, aberrant growth factor receptor signaling reprograms cellular metabolism and global gene transcription to drive aggressive growth, but the underlying mechanisms are not well-understood. Here we show that in the highly lethal brain tumor glioblastoma (GBM), mTOR complex 2 (mTORC2), a criti...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Masui, Kenta, Harachi, Mio, Ikegami, Shiro, Yang, Huijun, Onizuka, Hiromi, Yong, William H., Cloughesy, Timothy F., Muragaki, Yoshihiro, Kawamata, Takakazu, Arai, Nobutaka, Komori, Takashi, Cavenee, Webster K., Mischel, Paul S., Shibata, Noriyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926466/
https://ncbi.nlm.nih.gov/pubmed/31712311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011519
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