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Extracellular nutrients are required to maintain oncogenic signaling in brain cancer – a critical role for mTORC2

Mutations in growth factor receptor signaling pathways are common in cancer cells, including the highly lethal brain tumor glioblastoma (GBM) where they drive tumor growth through mechanisms including altering the uptake and utilization of nutrients. However, the impact of changes in micro-environme...

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Pubblicato in:Bioessays
Autori principali: Masui, Kenta, Shibata, Noriyuki, Cavenee, Webster K., Mischel, Paul S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501721/
https://ncbi.nlm.nih.gov/pubmed/27427440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201600026
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