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The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

Despite being surrounded by diverse nutrients, mammalian cells preferentially metabolize glucose and free amino acids. Recently, Ras-induced macropinocytosis of extracellular proteins was shown to reduce a transformed cell’s dependence on extracellular glutamine. Here, we demonstrate that protein ma...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Palm, Wilhelm, Park, Youngkyu, Wright, Kevin, Pavlova, Natalya N., Tuveson, David A., Thompson, Craig B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506698/
https://ncbi.nlm.nih.gov/pubmed/26144316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.06.017
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