mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma

In cancer, aberrant growth factor receptor signaling reprograms cellular metabolism and global gene transcription to drive aggressive growth, but the underlying mechanisms are not well-understood. Here we show that in the highly lethal brain tumor glioblastoma (GBM), mTOR complex 2 (mTORC2), a criti...

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Vydáno v:J Biol Chem
Hlavní autoři: Masui, Kenta, Harachi, Mio, Ikegami, Shiro, Yang, Huijun, Onizuka, Hiromi, Yong, William H., Cloughesy, Timothy F., Muragaki, Yoshihiro, Kawamata, Takakazu, Arai, Nobutaka, Komori, Takashi, Cavenee, Webster K., Mischel, Paul S., Shibata, Noriyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926466/
https://ncbi.nlm.nih.gov/pubmed/31712311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011519
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