Enhancing KCC2 function counteracts morphine-induced hyperalgesia

Morphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl(−) extruder KCC2 in the superficial dorsal horn (SDH) of the spinal...

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發表在:Sci Rep
Main Authors: Ferrini, Francesco, Lorenzo, Louis-Etienne, Godin, Antoine G., Quang, Miorie Le, De Koninck, Yves
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478677/
https://ncbi.nlm.nih.gov/pubmed/28634406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04209-3
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