Enhancing KCC2 function counteracts morphine-induced hyperalgesia

Morphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl(−) extruder KCC2 in the superficial dorsal horn (SDH) of the spinal...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Ferrini, Francesco, Lorenzo, Louis-Etienne, Godin, Antoine G., Quang, Miorie Le, De Koninck, Yves
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478677/
https://ncbi.nlm.nih.gov/pubmed/28634406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04209-3
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