Enhancing neuronal chloride extrusion rescues α2/α3 GABA(A)-mediated analgesia in neuropathic pain

Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported, raising questions on the best target to produce analgesia. Here, we show that nerve injury is associated with a reduction in the number of inhibit...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lorenzo, Louis-Etienne, Godin, Antoine G., Ferrini, Francesco, Bachand, Karine, Plasencia-Fernandez, Isabel, Labrecque, Simon, Girard, Alexandre A., Boudreau, Dominic, Kianicka, Irenej, Gagnon, Martin, Doyon, Nicolas, Ribeiro-da-Silva, Alfredo, De Koninck, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018745/
https://ncbi.nlm.nih.gov/pubmed/32054836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14154-6
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