Enhancing neuronal chloride extrusion rescues α2/α3 GABA(A)-mediated analgesia in neuropathic pain

Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported, raising questions on the best target to produce analgesia. Here, we show that nerve injury is associated with a reduction in the number of inhibit...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Lorenzo, Louis-Etienne, Godin, Antoine G., Ferrini, Francesco, Bachand, Karine, Plasencia-Fernandez, Isabel, Labrecque, Simon, Girard, Alexandre A., Boudreau, Dominic, Kianicka, Irenej, Gagnon, Martin, Doyon, Nicolas, Ribeiro-da-Silva, Alfredo, De Koninck, Yves
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018745/
https://ncbi.nlm.nih.gov/pubmed/32054836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14154-6
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki