Enhancing neuronal chloride extrusion rescues α2/α3 GABA(A)-mediated analgesia in neuropathic pain

Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported, raising questions on the best target to produce analgesia. Here, we show that nerve injury is associated with a reduction in the number of inhibit...

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Udgivet i:Nat Commun
Main Authors: Lorenzo, Louis-Etienne, Godin, Antoine G., Ferrini, Francesco, Bachand, Karine, Plasencia-Fernandez, Isabel, Labrecque, Simon, Girard, Alexandre A., Boudreau, Dominic, Kianicka, Irenej, Gagnon, Martin, Doyon, Nicolas, Ribeiro-da-Silva, Alfredo, De Koninck, Yves
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018745/
https://ncbi.nlm.nih.gov/pubmed/32054836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14154-6
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