BK channels in microglia are required for morphine-induced hyperalgesia

Although morphine is a gold standard medication, long-term opioid use is associated with serious side effects, such as morphine-induced hyperalgesia (MIH) and anti-nociceptive tolerance. Microglia-to-neuron signalling is critically involved in pain hypersensitivity. However, molecules that control m...

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Udgivet i:Nat Commun
Main Authors: Hayashi, Yoshinori, Morinaga, Saori, Zhang, Jing, Satoh, Yasushi, Meredith, Andrea L., Nakata, Takahiro, Wu, Zhou, Kohsaka, Shinichi, Inoue, Kazuhide, Nakanishi, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895018/
https://ncbi.nlm.nih.gov/pubmed/27241733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11697
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