Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl(−) homeostasis

A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We show here that hyperalgesia-inducing treatment with morphine causes downregulation of the K(+)-Cl(−) cotransporter KCC2, impairing Cl(−) homeostasis in spi...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Nat Neurosci
Главные авторы: Ferrini, Francesco, Trang, Tuan, Mattioli, Theresa-Alexandra M., Laffray, Sophie, Del’Guidice, Thomas, Lorenzo, Louis-Etienne, Castonguay, Annie, Doyon, Nicolas, Zhang, Wenbo, Godin, Antoine G., Mohr, Daniela, Beggs, Simon, Vandal, Karen, Beaulieu, Jean-Martin, Cahill, Catherine, Salter, Michael W., De Koninck, Yves
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974077/
https://ncbi.nlm.nih.gov/pubmed/23292683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3295
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы