Toll-Like Receptor 4 Mutant and Null Mice Retain Morphine-Induced Tolerance, Hyperalgesia, and Physical Dependence

The innate immune system modulates opioid-induced effects within the central nervous system and one target that has received considerable attention is the toll-like receptor 4 (TLR4). Here, we examined the contribution of TLR4 in the development of morphine tolerance, hyperalgesia, and physical depe...

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Hlavní autoři: Mattioli, Theresa Alexandra, Leduc-Pessah, Heather, Skelhorne-Gross, Graham, Nicol, Christopher J. B., Milne, Brian, Trang, Tuan, Cahill, Catherine M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019634/
https://ncbi.nlm.nih.gov/pubmed/24824631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097361
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