Chronic Morphine-Induced Changes in Signaling at the A(3) Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal

Treating chronic pain by using opioids, such as morphine, is hampered by the development of opioid-induced hyperalgesia (OIH; increased pain sensitivity), antinociceptive tolerance, and withdrawal, which can contribute to dependence and abuse. In the central nervous system, the purine nucleoside ade...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Doyle, Timothy M., Largent-Milnes, Tally M., Chen, Zhoumou, Staikopoulos, Vasiliki, Esposito, Emanuela, Dalgarno, Rebecca, Fan, Churmy, Tosh, Dilip K., Cuzzocrea, Salvatore, Jacobson, Kenneth A., Trang, Tuan, Hutchinson, Mark R., Bennett, Gary J., Vanderah, Todd W., Salvemini, Daniela
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2020
Témata:
Neuropharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372916/
https://ncbi.nlm.nih.gov/pubmed/32434943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000004
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