Chronic Morphine-Induced Changes in Signaling at the A(3) Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal

Treating chronic pain by using opioids, such as morphine, is hampered by the development of opioid-induced hyperalgesia (OIH; increased pain sensitivity), antinociceptive tolerance, and withdrawal, which can contribute to dependence and abuse. In the central nervous system, the purine nucleoside ade...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Doyle, Timothy M., Largent-Milnes, Tally M., Chen, Zhoumou, Staikopoulos, Vasiliki, Esposito, Emanuela, Dalgarno, Rebecca, Fan, Churmy, Tosh, Dilip K., Cuzzocrea, Salvatore, Jacobson, Kenneth A., Trang, Tuan, Hutchinson, Mark R., Bennett, Gary J., Vanderah, Todd W., Salvemini, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372916/
https://ncbi.nlm.nih.gov/pubmed/32434943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000004
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