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Spinal NADPH Oxidase is a Source of Superoxide in the Development of Morphine-Induced Hyperalgesia and Antinociceptive Tolerance

The role of superoxide and its active byproduct peroxynitrite as mediators of nociceptive signaling is emerging. We have recently reported that nitration and inactivation of spinal mitochondrial superoxide dismutase (MnSOD) provides a critical source of these reactive oxygen and nitrogen species dur...

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Détails bibliographiques
Auteurs principaux: Doyle, Tim, Bryant, Leesa, Muscoli, Carolina, Cuzzocrea, Salvatore, Esposito, Emanuela, Chen, Zhoumou, Salvemini, Daniela
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933278/
https://ncbi.nlm.nih.gov/pubmed/20637262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2010.07.013
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