SPINAL mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance

Treatment of severe pain by morphine, the gold-standard opioid and a potent drug in our arsenal of analgesic medications, is limited by the eventual development of hyperalgesia and analgesic tolerance. We recently reported that systemic administration of a peroxynitrite (PN) decomposition catalyst (...

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Detaylı Bibliyografya
Yayımlandı:Pain
Asıl Yazarlar: Little, Joshua W., Cuzzocrea, Salvatore, Bryant, Leesa, Esposito, Emanuela, Doyle, Timothy, Rausaria, Smita, Neumann, William L., Salvemini, Daniela
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874243/
https://ncbi.nlm.nih.gov/pubmed/23590939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2013.02.018
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