Spinal Ceramide and Neuronal Apoptosis in Morphine Antinociceptive Tolerance

Opiates, like morphine, are the most effective analgesics for treating acute and chronic severe pain, but their use is limited by the development of analgesic tolerance and hypersensitivity to innocuous and noxious stimuli. Because opioids are a mainstay of pain management, restoring their efficacy...

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Detalhes bibliográficos
Main Authors: Bryant, Leesa, Doyle, Tim, Chen, Zhoumo, Cuzzocrea, Salvatore, Masini, Emanuela, Vinci, M. Cristina, Esposito, Emanuela, Mazzon, Emanuela, Petrusca, Daniela Nicoleta, Petrache, Irina, Salvemini, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754041/
https://ncbi.nlm.nih.gov/pubmed/19631718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2009.07.051
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