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NADPH-oxidase 2 activation promotes opioid-induced antinociceptive tolerance in mice
The analgesic effectiveness of long-term opioid therapies is compromised by the development of antinociceptive tolerance linked to the overt production of peroxynitrite (ONOO(−), PN), the product of the interaction between superoxide (O(2)(˙−), SO) and nitric oxide (NO), and to neuroinflammatory pro...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4184413/ https://ncbi.nlm.nih.gov/pubmed/23454539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2013.02.042 |
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