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Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice

Severe pain syndromes reduce quality of life in patients with inflammatory and neoplastic diseases, often because chronic opiate therapy results in reduced analgesic effectiveness, or tolerance, leading to escalating doses and distressing side effects. The mechanisms leading to tolerance are poorly...

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Bibliografiske detaljer
Main Authors: Muscoli, Carolina, Cuzzocrea, Salvatore, Ndengele, Michael M., Mollace, Vincenzo, Porreca, Frank, Fabrizi, Francesca, Esposito, Emanuela, Masini, Emanuela, Matuschak, George M., Salvemini, Daniela
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045607/
https://ncbi.nlm.nih.gov/pubmed/17975673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32420
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