Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice

Severe pain syndromes reduce quality of life in patients with inflammatory and neoplastic diseases, often because chronic opiate therapy results in reduced analgesic effectiveness, or tolerance, leading to escalating doses and distressing side effects. The mechanisms leading to tolerance are poorly...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Muscoli, Carolina, Cuzzocrea, Salvatore, Ndengele, Michael M., Mollace, Vincenzo, Porreca, Frank, Fabrizi, Francesca, Esposito, Emanuela, Masini, Emanuela, Matuschak, George M., Salvemini, Daniela
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2007
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045607/
https://ncbi.nlm.nih.gov/pubmed/17975673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32420
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