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Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice

Severe pain syndromes reduce quality of life in patients with inflammatory and neoplastic diseases, often because chronic opiate therapy results in reduced analgesic effectiveness, or tolerance, leading to escalating doses and distressing side effects. The mechanisms leading to tolerance are poorly...

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Bibliografski detalji
Glavni autori: Muscoli, Carolina, Cuzzocrea, Salvatore, Ndengele, Michael M., Mollace, Vincenzo, Porreca, Frank, Fabrizi, Francesca, Esposito, Emanuela, Masini, Emanuela, Matuschak, George M., Salvemini, Daniela
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045607/
https://ncbi.nlm.nih.gov/pubmed/17975673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32420
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