Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice

Severe pain syndromes reduce quality of life in patients with inflammatory and neoplastic diseases, often because chronic opiate therapy results in reduced analgesic effectiveness, or tolerance, leading to escalating doses and distressing side effects. The mechanisms leading to tolerance are poorly...

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Bibliographische Detailangaben
Hauptverfasser: Muscoli, Carolina, Cuzzocrea, Salvatore, Ndengele, Michael M., Mollace, Vincenzo, Porreca, Frank, Fabrizi, Francesca, Esposito, Emanuela, Masini, Emanuela, Matuschak, George M., Salvemini, Daniela
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2007
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045607/
https://ncbi.nlm.nih.gov/pubmed/17975673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32420
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