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Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents

Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphi...

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Publicado en:J Neuroinflammation
Main Authors: Doyle, Timothy M., Hutchinson, Mark R., Braden, Kathryn, Janes, Kali, Staikopoulos, Vicky, Chen, Zhoumou, Neumann, William L., Spiegel, Sarah, Salvemini, Daniela
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584082/
https://ncbi.nlm.nih.gov/pubmed/33092620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01975-2
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