Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents

Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphi...

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Publicat a:J Neuroinflammation
Autors principals: Doyle, Timothy M., Hutchinson, Mark R., Braden, Kathryn, Janes, Kali, Staikopoulos, Vicky, Chen, Zhoumou, Neumann, William L., Spiegel, Sarah, Salvemini, Daniela
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Short Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584082/
https://ncbi.nlm.nih.gov/pubmed/33092620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01975-2
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