Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents

Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphi...

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Опубликовано в: :J Neuroinflammation
Главные авторы: Doyle, Timothy M., Hutchinson, Mark R., Braden, Kathryn, Janes, Kali, Staikopoulos, Vicky, Chen, Zhoumou, Neumann, William L., Spiegel, Sarah, Salvemini, Daniela
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2020
Предметы:
Short Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584082/
https://ncbi.nlm.nih.gov/pubmed/33092620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01975-2
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