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Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents

Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphi...

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發表在:J Neuroinflammation
Main Authors: Doyle, Timothy M., Hutchinson, Mark R., Braden, Kathryn, Janes, Kali, Staikopoulos, Vicky, Chen, Zhoumou, Neumann, William L., Spiegel, Sarah, Salvemini, Daniela
格式: Artigo
語言:Inglês
出版: BioMed Central 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584082/
https://ncbi.nlm.nih.gov/pubmed/33092620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01975-2
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