The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1

The ceramide-sphingosine 1-phosphate (S1P) rheostat is important in regulating cell fate. Several chemotherapeutic agents, including paclitaxel (Taxol), involve pro-apoptotic ceramide in their anticancer effects. The ceramide-to-S1P pathway is also implicated in the development of pain, raising the...

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Hlavní autoři: Janes, Kali, Little, Joshua W., Li, Chao, Bryant, Leesa, Chen, Collin, Chen, Zhoumou, Kamocki, Krzysztof, Doyle, Timothy, Snider, Ashley, Esposito, Emanuela, Cuzzocrea, Salvatore, Bieberich, Erhard, Obeid, Lina, Petrache, Irina, Nicol, Grant, Neumann, William L., Salvemini, Daniela
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110312/
https://ncbi.nlm.nih.gov/pubmed/24876379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569574
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