Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents

Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphi...

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Bibliografski detalji
Izdano u:J Neuroinflammation
Glavni autori: Doyle, Timothy M., Hutchinson, Mark R., Braden, Kathryn, Janes, Kali, Staikopoulos, Vicky, Chen, Zhoumou, Neumann, William L., Spiegel, Sarah, Salvemini, Daniela
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Short Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584082/
https://ncbi.nlm.nih.gov/pubmed/33092620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01975-2
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