Site-Specific Regulation of P2X7 Receptor Function in Microglia Gates Morphine Analgesic Tolerance

Tolerance to the analgesic effects of opioids is a major problem in chronic pain management. Microglia are implicated in opioid tolerance, but the core mechanisms regulating their response to opioids remain obscure. By selectively ablating microglia in the spinal cord using a saporin-conjugated anti...

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Dettagli Bibliografici
Pubblicato in:J Neurosci
Autori principali: Leduc-Pessah, Heather, Weilinger, Nicholas L., Fan, Churmy Y., Burma, Nicole E., Thompson, Roger J., Trang, Tuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596546/
https://ncbi.nlm.nih.gov/pubmed/28924009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0852-17.2017
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