Site-Specific Regulation of P2X7 Receptor Function in Microglia Gates Morphine Analgesic Tolerance

Tolerance to the analgesic effects of opioids is a major problem in chronic pain management. Microglia are implicated in opioid tolerance, but the core mechanisms regulating their response to opioids remain obscure. By selectively ablating microglia in the spinal cord using a saporin-conjugated anti...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Leduc-Pessah, Heather, Weilinger, Nicholas L., Fan, Churmy Y., Burma, Nicole E., Thompson, Roger J., Trang, Tuan
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596546/
https://ncbi.nlm.nih.gov/pubmed/28924009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0852-17.2017
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