Site-Specific Regulation of P2X7 Receptor Function in Microglia Gates Morphine Analgesic Tolerance

Tolerance to the analgesic effects of opioids is a major problem in chronic pain management. Microglia are implicated in opioid tolerance, but the core mechanisms regulating their response to opioids remain obscure. By selectively ablating microglia in the spinal cord using a saporin-conjugated anti...

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Vydáno v:J Neurosci
Hlavní autoři: Leduc-Pessah, Heather, Weilinger, Nicholas L., Fan, Churmy Y., Burma, Nicole E., Thompson, Roger J., Trang, Tuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596546/
https://ncbi.nlm.nih.gov/pubmed/28924009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0852-17.2017
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