Site-Specific Regulation of P2X7 Receptor Function in Microglia Gates Morphine Analgesic Tolerance

Tolerance to the analgesic effects of opioids is a major problem in chronic pain management. Microglia are implicated in opioid tolerance, but the core mechanisms regulating their response to opioids remain obscure. By selectively ablating microglia in the spinal cord using a saporin-conjugated anti...

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Publicado en:J Neurosci
Autores principales: Leduc-Pessah, Heather, Weilinger, Nicholas L., Fan, Churmy Y., Burma, Nicole E., Thompson, Roger J., Trang, Tuan
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2017
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596546/
https://ncbi.nlm.nih.gov/pubmed/28924009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0852-17.2017
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