Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl(−) homeostasis

A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We show here that hyperalgesia-inducing treatment with morphine causes downregulation of the K(+)-Cl(−) cotransporter KCC2, impairing Cl(−) homeostasis in spi...

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Pubblicato in:Nat Neurosci
Autori principali: Ferrini, Francesco, Trang, Tuan, Mattioli, Theresa-Alexandra M., Laffray, Sophie, Del’Guidice, Thomas, Lorenzo, Louis-Etienne, Castonguay, Annie, Doyon, Nicolas, Zhang, Wenbo, Godin, Antoine G., Mohr, Daniela, Beggs, Simon, Vandal, Karen, Beaulieu, Jean-Martin, Cahill, Catherine, Salter, Michael W., De Koninck, Yves
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974077/
https://ncbi.nlm.nih.gov/pubmed/23292683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3295
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