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Enhancing KCC2 function counteracts morphine-induced hyperalgesia
Morphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl(−) extruder KCC2 in the superficial dorsal horn (SDH) of the spinal...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5478677/ https://ncbi.nlm.nih.gov/pubmed/28634406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04209-3 |
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