Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling

In response to virus infection, RIG-I-like receptors (RLRs) sense virus RNA and induce MAVS to form prion-like aggregates to further propagate antiviral signalling. Although monomeric MAVS recombinant protein can assemble into prion-like filaments spontaneously in vitro, endogenous MAVS in cells is...

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Pubblicato in:Nat Commun
Autori principali: Qi, Nan, Shi, Yuheng, Zhang, Rui, Zhu, Wenting, Yuan, Bofeng, Li, Xiaoyan, Wang, Changwan, Zhang, Xuewu, Hou, Fajian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474743/
https://ncbi.nlm.nih.gov/pubmed/28607490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15676
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