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Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity
Innate immunity plays a pivotal role in virus infection. RIG-I senses viral RNA and initiates an effective innate immune response for type I interferon production. To transduce RIG-I-mediated antiviral signalling, a mitochondrial protein MAVS forms prion-like aggregates to activate downstream kinase...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5418627/ https://ncbi.nlm.nih.gov/pubmed/28469175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15138 |
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